Nce of DVT after TKA. Keywords: Deep venous thrombosis, Global thrombosis test, ThrombolysisBackground Deep venous thrombosis (DVT), which may cause serious pulmonary embolism (PE), is a fatal disease because of its high morbidity and mortality [1-3]. DVT is the most feared complication of major joint arthroplasy such as total hip arthroplasity (THA) and total knee arthroplasty (TKA) [4,5]. Despite advances* Correspondence: matsuo-o@med.kindai.ac.jp 5 Kinki University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan Full list of author information is available at the end of the articlein surgical technique and clinical managements, patients undergoing these surgeries in the lower limbs remain at high risk for DVT and PE. Although DVT is often occurred within 24?8 hours after TKA, there is also a case that DVT is occurred on the day after this 1-Bromo-2-fluoro-4-methoxy-5-nitrobenzene surgery [6]. It is therefore critical to predict the occurrence of DVT as early as possible for the prevention of PE in these patients. However, there is presently no single laboratory marker available to predict or exclusively confirm the diagnosis of DVT [7,8].?2014 Tamura et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative 5-Fluoro-3-nitropyridin-2(1H)-one Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Tamura et al. Thrombosis Journal 2014, 12:11 http://www.thrombosisjournal.com/content/12/1/Page 2 ofThe most widely accepted and utilized assay, D-dimer, is highly sensitive and therefore useful for exclusion of the disease but lacks the specificity necessary to confirm the diagnosis [7]. For this reason additional studies including duplex ultrasound, venography, V/Q scanning, helical thoracic and pelvic CT scans and pulmonary angiography remain the standard for diagnosis of DVT and PE. The global thrombosis test (GTT) is a novel comprehensive test of platelet reactivity, coagulation, and spontaneous thrombolytic activity [9]. As this test is performed from whole (non-anticoagulated) blood, it is genuinely different, and free from many of the shortcomings of conventional platelet test and coagulation, which employ citrate-anti-coagulated blood [9-14]. The aim of the present study was to investigate whether this novel test of overall thrombotic and thrombolytic status can predict the incidence of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/17591728 DVT in patient with undergoing TKA.MethodsStudy populationThe study protocol was approved by the Ethics Committee of Kinki University Faculty of Medicine (Osakasayama, Japan), and written informed consent was obtained from each patient. The study included 31 patients (3 male and 28 female) with osteoarthritis (n = 24), rheumatoid arthritis (n = 6) and ankylosing spondylitis (n = 1), who underwent TKA consecutively between September 2010 and November 2011 by well-trained operator who has been performing TKA more than 28 years experience of TKA. The patients ranged in age from 55 to 84 years (mean ?SD, 72.3 ?7.6 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/8833965 years). The medication of anti-coagulant, such as heparin was discontinued a week before surgery in patients undergoing anticoagulative theraphy. The total operation time was 86 ?11 min.Doppler ultrasonographyFigure 1 The diffe.